Anti-Epileptic Effects of TRH-T and DN-1417
نویسندگان
چکیده
منابع مشابه
Effects of TRH and an analog, DN-1417 on the activities of single neurons in the nucleus accumbens, cerebral cortex and caudate-putamen of rats.
The actions of TRH and its analog, y butyrolactone y -carbonyl histidyl prolinamide citrate (DN-1417) on the unit activities of the cerebral cortex, caudate -putamen and nucleus accumbens were examined using a microelec trophoretic technique in anesthetized rats. Over 80% of the neurons examined in the nucleus accumbens responded to TRH and DN -1417. The effects were mainly inhibitory, but exci...
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15 صفحه اولA thyrotropin releasing hormone analog, DN-1417, increases endogenous dopamine release from slices of rat striatum and nucleus accumbens.
Besides its hormonal effects, thyrotro pin releasing hormone (TRH) induces se veral behavioral changes in rats. Marked increases in locomotor activity occur after administration of TRH and its analogs. This effect was hypothesized to be due to a stimulation of mesolimbic dopaminergic neurons (Miyamoto and Nagawa, 1977; Heal and Green, 1979). TRH has no effect on the reuptake of monoamines (Tuom...
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ژورنال
عنوان ژورنال: The Kurume Medical Journal
سال: 1983
ISSN: 0023-5679,1881-2090
DOI: 10.2739/kurumemedj.30.supplement_s57